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Found 203 Enz. Inhib. hit(s) with Target = 'Adenomatous polyposis coli protein'
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407493(CHEMBL5288446)
Affinity DataKi:  15nMAssay Description:Relative potency against Histamine H1 receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50369190(CHEMBL4163133)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407492(CHEMBL5280732)
Affinity DataKi:  120nMAssay Description:Apparent pA2 value of compound at 50 nM concentration of mepyramine in rat aortaMore data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407464(CHEMBL5289275)
Affinity DataKi:  2.41E+3nMAssay Description:Apparent pA2 value of compound at 10 nM concentration of mepyramine in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407467(CHEMBL5289169)
Affinity DataKi:  3.12E+3nMAssay Description:Antagonistic activity for carbachol induced contractions in guinea pig ileum against Muscarinic acetylcholine receptor M3 in the presence of mepyrami...More data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407491(CHEMBL5282293)
Affinity DataKi:  3.80E+3nMAssay Description:Antagonistic activity for carbachol induced contractions in guinea pig ileum against Muscarinic acetylcholine receptor M3 in the presence of mepyrami...More data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686](Homo sapiens (Human))
University Of Utah Research Foundation

US Patent
LigandPNGBDBM50094484(CHEBI:3556 | CHEMBL2323033 | US9284299, CGP049090 ...)
Affinity DataKi:  8.31E+3nM ΔG°:  -29.0kJ/molepH: 7.4 T: 2°CAssay Description:Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50407461(CHEMBL5274458)
Affinity DataKi:  4.46E+4nMAssay Description:Tetsed for Antagonistic activity at histamine H3 receptor in guinea pig ileal longitudinal muscle in the presence of mepyramine at a concentration of...More data for this Ligand-Target Pair
In DepthDetails
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM50481595(CHEMBL5287183)
Affinity DataKi:  4.46E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetAdenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686](Homo sapiens (Human))
University Of Utah Research Foundation

US Patent
LigandPNGBDBM213748(US9284299, PKF115-584 | US9738628, Compound PKF115...)
Affinity DataKi:  5.39E+4nM ΔG°:  -24.4kJ/moleT: 2°CAssay Description:Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686](Homo sapiens (Human))
University Of Utah Research Foundation

US Patent
LigandPNGBDBM50094484(CHEBI:3556 | CHEMBL2323033 | US9284299, CGP049090 ...)
Affinity DataKi:  6.25E+4nM ΔG°:  -24.0kJ/moleT: 2°CAssay Description:Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686](Homo sapiens (Human))
University Of Utah Research Foundation

US Patent
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataKi:  6.62E+4nM ΔG°:  -23.9kJ/molepH: 7.4 T: 2°CAssay Description:Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686](Homo sapiens (Human))
University Of Utah Research Foundation

US Patent
LigandPNGBDBM213761(US9284299, 12 | US9738628, Compound 12)
Affinity DataKi:  1.71E+5nM ΔG°:  -21.5kJ/molepH: 7.4 T: 2°CAssay Description:Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686](Homo sapiens (Human))
University Of Utah Research Foundation

US Patent
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataKi:  1.71E+5nM ΔG°:  -21.5kJ/moleT: 2°CAssay Description:Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686](Homo sapiens (Human))
University Of Utah Research Foundation

US Patent
LigandPNGBDBM213761(US9284299, 12 | US9738628, Compound 12)
Affinity DataKi:  1.76E+5nM ΔG°:  -21.4kJ/moleT: 2°CAssay Description:Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM273137(US10071086, Compound 443)
Affinity DataIC50:  1nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM269261(US10071086, Compound 9)
Affinity DataIC50:  1.20nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM271118(US10071086, Compound 382)
Affinity DataIC50:  3nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM269257(US10071086, Compound 5)
Affinity DataIC50:  3.90nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM271120(US10071086, Compound 440)
Affinity DataIC50:  4nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM269254(US10071086, Compound 1)
Affinity DataIC50:  6nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM269255(US10071086, Compound 2)
Affinity DataIC50:  6nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM269259(US10071086, Compound 7)
Affinity DataIC50:  6nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM270609(US10071086, Compound 158)
Affinity DataIC50:  8nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275757(US10071086, Compound 785)
Affinity DataIC50:  10nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM270606(US10071086, Compound 114)
Affinity DataIC50:  11nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM270617(US10071086, Compound 229)
Affinity DataIC50:  12nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275764(US10071086, Compound 888)
Affinity DataIC50:  12nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM270451(US10071086, Compound 18)
Affinity DataIC50:  13nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275758(US10071086, Compound 793)
Affinity DataIC50:  16nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275761(US10071086, Compound 803)
Affinity DataIC50:  17nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275735(US10071086, Compound 605)
Affinity DataIC50:  18nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275734(US10071086, Compound 602)
Affinity DataIC50:  18nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275730(US10071086, Compound 590)
Affinity DataIC50:  20nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM270306(US10071086, Compound 12)
Affinity DataIC50:  21nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM270480(US10071086, Compound 24)
Affinity DataIC50:  21nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275503(US10071086, Compound 458)
Affinity DataIC50:  22nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275609(US10071086, Compound 552)
Affinity DataIC50:  22nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275754(US10071086, Compound 765)
Affinity DataIC50:  27nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275740(US10071086, Compound 643)
Affinity DataIC50:  30nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM270471(US10071086, Compound 22)
Affinity DataIC50:  32nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275759(US10071086, Compound 797)
Affinity DataIC50:  32nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275598(US10071086, Compound 551)
Affinity DataIC50:  33nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275738(US10071086, Compound 635)
Affinity DataIC50:  34nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275737(US10071086, Compound 621)
Affinity DataIC50:  36nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM269255(US10071086, Compound 2)
Affinity DataIC50:  38nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275749(US10071086, Compound 728)
Affinity DataIC50:  39nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275495(US10071086, Compound 452)
Affinity DataIC50:  48nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275752(US10071086, Compound 758)
Affinity DataIC50:  48nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenomatous polyposis coli protein(Homo sapiens (Human))TBA
LigandPNGBDBM275666(US10071086, Compound 581)
Affinity DataIC50:  48nMAssay Description:Reporter cell lines can be generated by stably transducing cells of cancer cell lines (e.g., colon cancer) with a lentiviral construct that include a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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